When the notorious Diaper Mafia takes the Tromaville School for the Very Special hostage, only the Toxic Avenger and his morbidly obese sidekick Lardass can save Tromaville. However, an explosion results in some unforeseeable consequences, creating a dimensional tear between Tromaville and its dimensional mirror image, Amortville. While the Toxic Avenger (Toxie) is trapped in Amortville, Tromaville comes under the control of Toxie's evil doppelganger, the Noxious Offender (Noxie).

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